Acid-Associated Heartburn Symptoms and Dose of Esomeprazole

Inclusion Criteria

• - Males and non-lactating females, aged 18 to 75 years, inclusive, with the ability to understand English and provide written informed consent
• - A history of heartburn for at least 6 months
• - A history of prior positive relief of heartburn symptoms from antacids or acid suppressive therapy
• - A positive esophageal acid perfusion test
• - At least 3 days of ‘moderate’ severity heartburn over the previous 7 days
• - No use of any acid suppression therapy (PPI, H2RA, etc.) within 14 days of randomization