A study to assess the pharmacokinetics of AZD6793 when administered alone and in combination with itraconazole in healthy participants.

Exclusion Criteria

• -History of any clinically significant disease or disorder which may either put the participant at risk because of participation in the study or influence the results or the participant's ability to participate in the study.
• -History or presence of gastrointestinal, hepatic, renal, or pancreatic disease, or any other clinically significant disease or disorder known to interfere with absorption, distribution, metabolism, or excretion of drugs.
• -History of clinically significant chronic or active hematologic disease.
• -Diagnosis or history of immunodeficiency or increased susceptibility to severe infection, or a clinically significant infection within 4 weeks of the Screening Visit.
• -Any clinically important illness, medical/surgical procedure or trauma within 4 weeks of the first administration of study drug.
• -Any laboratory values with deviations at the Screening Visit or on admission to the Clinical Unit. Abnormal values may be repeated at the discretion of the Investigator: Alanine transaminase (ALT) > Upper Limit Normal (ULN), Aspartate Transaminase (AST) > ULN, WBC count < Lower limit normal (LLN), Neutrophils > ULN or < LLN, Haemoglobin < 120 g/L, Bilirubin > ULN, Urinary albumin to creatinine ratio abnormal (≥ 3.4 mg/mmol), eGlomerular filtration rate (eGFR) < 85 mL/min/1.73 m² calculated using the CKD-EPI equation (eGFR will only be assessed at Screening).
• -Any clinically important abnormalities in clinical chemistry, haematology, or urinalysis results at the screening.
• -Positive or indeterminate QuantiFERON® TB test at the Screening Visit.
• -Any positive result on screening for serum hepatitis B surface antigen, hepatitis C antibody, or Human immunodeficiency virus (HIV).
• -Participants with a history or presence of vitiligo or significant (in the opinion of the investigator) skin depigmentation for any cause including drugs.
• -Any clinically significant abnormal finding in vital signs, at the Screening Visit and/or on admission to the Clinical Unit.
• -Any clinically important abnormalities in rhythm, conduction or morphology of the resting electrocardiogram (ECG) and any clinically important abnormalities in the 12 lead ECG.
• -Current smokers or those who have smoked or used nicotine products (including e-cigarettes) within the 3 months prior to screening.
• -Known or suspected history of alcohol or drug abuse or excessive intake of alcohol.
• -Positive screen for drugs of abuse, alcohol, or cotinine (nicotine) at screening visit or on admission to the Clinical Unit.
• -History or presence of severe allergy/hypersensitivity.
• -Excessive intake of caffeine-containing drinks or food.
• -Use of drugs with enzyme-inducing properties such as St John's Wort within 3 weeks prior to the first administration of the study drug.
• -Use of any prescribed or nonprescribed medication including antacids, analgesics (other than paracetamol/acetaminophen), herbal remedies, mega dose vitamins (intake of >3 times the recommended daily dose) and minerals during the 2 weeks or 5 half-lives of the medication, whichever is longer, prior to the first administration of study drug. The use of hormonal replacement therapy for females is not permitted.
• -Plasma donation within 1 month of screening or any blood donation/loss more than 500 mL during the 3 months prior to screening.
• -Has received another new chemical entity (defined as a compound which has not been approved for marketing) within 30 days or 5 half-lives (whichever is longest) of the first administration of study intervention in this study.
• -Participants who have previously received AZD6793.
• -Vulnerable participants.
• -Participant has a positive test result for SARS-CoV-2 via RT-PCR on admission to the Clinical Unit.
• -Participant has clinical signs and symptoms consistent with Coronavirus disease 2019 (COVID-19).
• -Participant who had severe course of COVID-19.