Oral mucosal absorption of ICI176,334-1

Exclusion Criteria

• - Presence of any disease under medical treatment
• - History or presence of cardiovascular, respiratory, hepatic, renal, gastrointestinal, immunological, blood, endocrine, neurological or mental disease to interfere with absorption, distribution, metabolism or excretion of drugs judged by investigator(s)
• - Presence of any infectious disease, such as bacteria, virus and fungus Presence of allergic disorder, such as asthma, pollen disease or atopic dermatitis, and judged as necessary any medical treatment
• - Any large surgical history of gastrointestinal tract such as gastric/intestinal resection or suturation