Study to assess the safety and tolerability of MEDI5117 in Rheumatoid Arthritis patients

Exclusion Criteria

• - History or presence of any clinically significant disease or disorder which has not been stable over the previous 3 months.
• - History of liver disease, bilirubin elevations, or Gilbert's Syndrome.
• - Any systematic inflammatory condition in addition to RA (polymyalgia rheumatica, giant cell arthritis, systemic lupus, gout, pyrophosphate arthropathy).
• - Current, chronic pain disorders including fibromyalgia and chronic regional pain syndromes or chronic fatigue syndromes.
• - Intramuscular steroid injection or intraarticular steroid injection within 1 month of enrollment.