Durvalumab Consolidation after Chemoradiation Therapy for Limited Stage SCLC in China - DREAM

Inclusion Criteria

• Inclusion Criteria:
• • Able to provide informed consent
• • Age ≥18 years
• • Histologically or cytologically documented LS-SCLC (Stage I-III SCLC [T any, N any, M0] according to the American Joint Committee on Cancer Staging Manual [AJCC Cancer Staging Manual, 8th Edition], that can be safely treated with definitive radiation doses. Excludes T3-4 due to multiple lung nodules that are too extensive or have tumor/nodal volume that is too large to be encompassed in a tolerable radiation plan)
• • ECOG PS 0-2 (prior to the first dose of durvalumab after CRT)
• • No disease progression following cCRT/sCRT (cCRT refers to chemotherapy and radiotherapy are administered with overlap; sCRT refers to chemotherapy and radiotherapy are delivered in a sequential manner with no overlap)
• • Patients who received platinum-based cCRT/sCRT followed by durvalumab consolidation as first-line treatment at the discretion of physicians are eligible (the time interval from the end of cCRT/sCRT to the first dose of durvalumab consolidation should be within 3 months)
• o Patients who started durvalumab consolidation ≤3 months before enrolment in the study will be allowed (irrespective of whether they continue to receive durvalumab at time of enrolment or already discontinued treatment)
• Exclusion Criteria:
• • Patients treated with CRT only without subsequent durvalumab consolidation
• • Patients received durvalumab or any other anti-PD-1/anti-PD-L1 antibodies along with CRT
• • Patients who previously were involved, or currently are, or plan to be involved in any other interventional anti-cancer clinical studies for LS-SCLC
• • Prior exposure to immune-mediated therapy including, but not limited to, other anti-PD-1, anti-PD-L1, and anti-PD-L2 antibodies, excluding therapeutic anticancer vaccines
• • Judgment by the investigator that the patient should not participate in the study because the patient is unlikely to comply with study procedures