Prevention of Stroke and Systemic Embolic Events in Patients with Atrial Fibrillation

Exclusion Criteria

• - AF secondary to reversible disorders, eg hyperthyroidism, drugs and pulmonary embolism
• - Known contraindication to VKA treatment
• - Presence of a valvular heart disease, mechanical heart valves, active endocarditis, left ventricular aneurysm or thrombus, atrial myxoma or any condition other than AF requiring chronic anticoagulation treatment
• - Conditions associated with increased risk of major bleeding for example: history of intracranial bleeding, history of bleeding gastrointestinal disorder or major surgical procedure or trauma two weeks prior to randomization