A Study to Evaluate BioMarkers in Blood Samples in Subjects with Rheumatoid Arthritis

Exclusion Criteria

• - History or current inflammatory joint disease other than RA, OA, or pseudogout (eg, gout, reactive arthritis, psoriatic arthritis, seronegative spondyloarthropathy, Lyme disease) or other autoimmune disorder (systemic lupus erythematosus, inflammatory bowel disease, scleroderma, inflammatory myopathy, or overlap syndrome).
• - Any neurological (congenital or acquired), psychiatric, vascular, or systemic disorder could also affect the evaluation of disease assessments; in particular, joint pain and swelling.
• - Treatment with IFN-α or IFN-β.
• - Intra-articular, IM, or IV corticosteroid injections within 28 days before screening (Day 1).
• - Known history of or positive test result for human immunodeficiency virus (HIV).
• - Serious infection (eg, pneumonia, septicemia) within the 2 months prior to Day 1 visit.
• - Active bacterial or viral infection (which includes ongoing and/or chronic infections such as hepatitis, tuberculosis, etc).
• - Concomitant use of systemic antiviral, antibiotic, or antifungals for the treatment of active infection within 28 days of Day 1.
• - History of malignancy or evidence of active or suspected malignancy (with the exception of adequately treated basal cell carcinoma of the skin or in situ carcinoma of the uterine cervix > 1 year before randomization into the study).
• - Vaccinations within 4 weeks of Day 1 visit.
• - Concurrent enrollment in another clinical study.
• - Employees of the clinical study site or any other individuals involved with the conduct of the study, or immediate family members of such individuals.
• - Other unspecified reasons that, in the opinion of the Investigator or medical monitor, make the subject unsuitable for participation or confound the data.